Tips:
Tracing the dynamic changes before and after the treatment of ICB will help us explore the influence of ICB on both tumor and immune system. This module integrated all patients from which samples with the same tissue type have been biopsied both pre and post the ICB treatment. Then, users could select an interested cancer type and dataset, and then select a certain tissue type and cell type to see the dynamic changes before and after the ICB. Firstly, a volcano plot is intuitively presented for users to show the underlying significantly differential expressed genes. Secondly, detailed differential gene expression table will also be returned so that users can screen genes they are interested in and check their up or down trend during the treatment of ICB. Thirdly, the GO and KEGG enrichment results of specific up-regulated genes in both Pre and Post treatment group will also be returned so that users can directly know which signaling pathways or gene signatures are enriched in Pre or Post ICB group. All clinical information, expression table and figures for visualization can be downloaded.